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  Modelling networks from sequence to consequence in eukaryotes 28-29 March 2011 Royal Society UK (FREE) Minimize
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How to integrate genetic mapping and high-throughput data to explain functional variation
 Concept of eQTL mapping Minimize

eQTL map
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 Challenges Minimize
• Reverse engineering of gene
  networks
• Mining the public domain
• Optimizing the experiments
• Biological Interpretation
• Integration of all these
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 Reverse engineering of networks Minimize

Nodes: genes Edges: (Cor)relations ‘Learn’ network from data

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 Bioinformatics Minimize
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 What is GeneSys? Minimize
•BBSRC funded research network
•Objective: Integration & dissemination of knowledge to facilitate dissection of the genetics of functional variation
•First meeting 1-3 October e-Science Centre, Edinburgh
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Dissection of functional variation using eQTL studies requires integration of advanced computational and bioinformatics tools
The GENESYS network will facilitate this integration
The GeneSys network is funded by the BBSRC under the ‘Mathematics for Systems Biology” (MATSYB) initiative
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